Brian A. Aguado

This study shows gonadal and chromosomal sex independently and together affect immune responses to implanted scaffolds in mice.

This study decouples the effects of sex chromosomes and gonadal sex on cardiac myofibroblast activation using FCG mice and hydrogel cultures, revealing sex-specific gene and protein expression patterns.

The paper identifies IGFBP2 as a sex-specific serum biomarker predicting Evogliptin resistance in female aortic valve stenosis patients.

This study shows TGF-β1 causes sex-specific cardiac myofibroblast activation and secreted factor differences on hydrogels, influencing fibrosis.

This study uses spatial transcriptomics to identify sex differences in gene expression and cell interactions near calcification sites in human aortic valves.

This study uses an AI platform to identify sex-specific drug combinations targeting aortic valve myofibroblast activation, revealing sex-dependent efficacy and interactions.

The paper investigates how UTY modulates sex-specific methylation in male valvular fibroblasts in response to nanoscale extracellular matrix cues, promoting osteoblast-like cell phenotypes in aortic valve stenosis.

The paper investigates how inflammatory cytokines from macrophages differentially affect male and female valvular interstitial cells on hydrogel biomaterials, revealing sex-specific mechanisms in myofibroblast activation and osteoblast-like differentiation.

The paper uses network modeling to predict gene expression and drug responses in valve myofibroblasts exposed to patient sera, linking fibrosis-related signaling to AVS severity and identifying potential therapeutic targets.