Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- MicrobiologybioRxivPreprint
Gain-of-function mutations in 1-phosphofructokinase (FruK) re-establish glycolysis in bacteria
- MicrobiologybioRxivPreprint
Coupling Complementary Pathways in a Bacterial Co-culture Enables 4-Aminophenol Removal during Paracetamol Degradation
Francesca Demaria, Matthias Schaffter, Cristina Zimmardi…·Philippe Corvini
This study shows that a co-culture of Delftia P1 and Microbacterium lacus efficiently removes paracetamol and its toxic metabolite 4-AP by coupling their degradation pathways.
DOI 10.64898/2026.11.11.765863 - MicrobiologybioRxivPreprint
EveD, a vesicle-associated rhizobial candidate effector shaping nodulation competitiveness and host genotype responses
Diego García-Rodríguez, Paula Ayala-García, Francisco Pérez-Montaño…·Irene Jiménez-Guerrero
The paper identifies EveD, a rhizobial protein in EVs that affects nodule competitiveness and genotype-specific symbiotic responses in legumes.
DOI 10.64898/2026.11.12.766089 - MicrobiologybioRxivPreprint
Candidatus Pannonibacter alzirae sp. nov. isolated from a septic immunocompromised patient in Brazil
Igor Vasconcelos Rocha, Beatriz Souza Toscano de Melo, João Luiz de Lemos Padilha Pitta…·Matheus Filgueira Bezerra
The paper describes the genomic and phenotypic characterization of a novel Pannonibacter species isolated from a septic immunocompromised patient, highlighting its distinct features and potential for opportunistic infections.
DOI 10.64898/2026.11.11.765890 - MicrobiologybioRxivPreprint
A polarized genome is required for fitness of the obligate intracellular, tick-borne pathogen Rickettsia parkeri
Trung Nguyen, Andrew C Krusenstjerna, Mathilde Gonin…·Erin D Goley
This study shows that genome polarization is essential for Rickettsia parkeri's fitness, as disrupting polar proteins causes cell division defects and reduced host cell spread.
DOI 10.64898/2026.11.11.765969 - MicrobiologybioRxivPreprint
A bivalent VP2 based vaccine approach reveals co expression driven interference between VP2 antigens impairing BTV neutralizing antibody induction
Luis Jimenez-Cabello, Juana Sanchez-Puig, Ivan Mazuecos-Aragones…·Javier Ortego
This study develops a bivalent vaccine approach using BTV VP2 antigens and finds that co-expression of VP2 proteins interferes with neutralizing antibody induction, while monovalent vaccines provide effective protection.
DOI 10.64898/2026.11.11.764333 - MicrobiologybioRxivPreprint
Outbreaks of Newcastle Disease Virus Genotype VII.1.1 in Vaccinated Commercial Poultry, Germany, 2026
Hannes Bergmann, Annett Rudovsky, Christian Grund…·Carola Sauter-Louis
This study reports outbreaks of Newcastle Disease Virus genotype VII.1.1 in vaccinated poultry in Germany in 2026, highlighting the need for improved surveillance.
DOI 10.64898/2026.11.11.765530 - MicrobiologybioRxivPreprint
Ultra-small bacteria and their phages discovered through metagenomics in a sub-arctic degrading permafrost ecosystem
Nea Tuomela, Tatiana Demina, David Neville Thomas…·Jenni Hultman
The paper uses metagenomics to discover ultra-small bacteria and their phages in a sub-arctic permafrost ecosystem, revealing their distribution and metabolic traits.
DOI 10.64898/2026.11.11.765320 - MicrobiologybioRxivPreprint
Mechanical unloading and exercise volume differentially modulate the gut microbiome and intestinal gene expression in mice
Seif Hundam, Mohammad Borhan Al-Zghoul, Shahed Ogiliat…·Shadi Shahatit
This study examines how hindlimb suspension and different exercise volumes affect gut microbiome composition and intestinal gene expression in mice, finding reduced microbial richness with suspension and distinct transcriptional responses with exercise.
DOI 10.64898/2026.11.11.765836 - MicrobiologybioRxivPreprint
Strain-specific early, host-shaped late: the rhizobial transcriptome across symbiosis
Sebastián Acosta-Jurado, Francisco Fuentes-Romero, Pilar Navarro-Gómez…·José María Vinardell
This paper compares the transcriptomes of rhizobial bacteroids across different host plants, identifying strain-specific and host-common gene responses during symbiosis.
DOI 10.64898/2026.11.11.765592 - MicrobiologybioRxivPreprint
Development of African Swine Fever Virus Pseudotype Systems for Ba71v and Georgia 2007 strains
George L Hooper, Edward Wright, Christopher L Netherton
This study develops pseudotype systems for ASFV Ba71v and Georgia 2007 strains to study cell entry mechanisms safely under lower containment.
DOI 10.64898/2026.11.12.765316 - MicrobiologybioRxivPreprint
A conserved tyrosine in the S1/S2 loop shapes SARS-CoV-2 spike processing and host protease usage.
William M Meyers, Angelica L Morgan, Michelle N. Vu…·Vineet D Menachery
This study shows that phosphorylation at Y674 in the SARS-CoV-2 spike S1/S2 loop affects spike processing and protease usage, impacting viral replication and pathogenesis.
DOI 10.64898/2026.11.12.766136 - MicrobiologybioRxivPreprint
RAMP-Seq: a single-tube nanopore workflow for co-amplifying full-length 16S rRNA and antimicrobial resistance genes for integrated taxonomic and resistance profiling
Deepali Pathak, Suraj Jagtap, Rekha Godbole…·Rahul Roy
RAMP-Seq co-amplifies full-length 16S rRNA and antimicrobial resistance genes in a single PCR, enabling integrated taxonomic and resistance profiling across diverse samples.
DOI 10.64898/2026.11.12.766053 - MicrobiologybioRxivPreprint
Cryo-EM Structure of Mycobacteriophage D29 Reveals a Specialized Portal-Capsid Junction and a Unique 13-Subunit Baseplate Collar
The paper determines the cryo-EM structure of mycobacteriophage D29, revealing structural adaptations at symmetry-mismatched interfaces and their role in host recognition.
DOI 10.64898/2026.11.10.765797 - MicrobiologybioRxivPreprint
Multi-specific nanobody-Fc fusions against TcdB protect in vivo from diverse Clostridioides difficile strains
Alyssa G. Ehni, Bruno B. C. Lança, Heather K. Kroh…·D. Borden Lacy
This study develops multi-specific nanobody-Fc fusions targeting TcdB that neutralize diverse C. difficile strains and improve infection outcomes in mice.
DOI 10.64898/2026.11.12.766007 - MicrobiologybioRxivPreprint
Characterization of anaerobic bacterial populations putatively involved in the degradation of Chlorine pesticides in mangrove soils of Guadeloupe (Lesser Antilles).
This study characterizes bacterial communities in mangrove soils contaminated with chlordecone, identifying genera involved in its degradation and suggesting mangroves have purification potential.
DOI 10.64898/2026.11.12.766228