Dana Borden Lacy

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

The paper identifies a targeted cell lysis mechanism driven by TcdE that facilitates toxin release in Clostridioides difficile, revealing it as a bet-hedging strategy.

This study shows that C. difficile toxins A and B inhibit their own antigen-specific immune responses via glucosyltransferase activity, contributing to recurrent infections.

This study investigates whether inhibiting EGFR/ErbB receptors protects against C. difficile toxin B, finding no protective effect.