Jay Vornhagen

Repurposing antiviral drugs as a new avenue for Klebsiella pneumoniae decolonization

This study identifies antiviral drugs with anti-Klebsiella pneumoniae activity, showing strain-specific effects and resistance mechanisms, suggesting their potential for gut decolonization.

Sugar Import Suppresses Klebsiella pneumoniae Mucoidy in cAMP-CRP-dependent Manner

This study shows that sugar import, not catabolism, suppresses mucoidy in hypervirulent K. pneumoniae via cAMP-CRP signaling, reducing rmpADC promoter activity and rmpD expression.

A Novel Technique to Characterize Klebsiella pneumoniae Populations Indicates that Mono-Colonization is Associated with Risk of Infection

This paper develops wzi-Seq, a method to detect and quantify Klebsiella strains in gut samples, and finds that mono-colonization is associated with increased infection risk.

Pseudomonas aeruginosa phenazines dictate site-specific competitive interactions with Klebsiella pneumoniae

This study shows that Pseudomonas aeruginosa uses phenazines to inhibit Klebsiella pneumoniae growth, with strain-specific and site-dependent effects.

From prototype to outbreak: conserved pathogenesis of Oropouche virus in a novel murine pregnancy model highlights its public health implications

This study establishes a murine model showing Oropouche virus can vertically transmit from mother to fetus, confirming its long-standing ability and public health risks.

Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae

This paper reclassifies SHV β-lactamase alleles in K. pneumoniae genomes based on mutations, improving genotype-phenotype understanding and updating the Kleborate tool.

Type-2 diabetes mellitus enhances Klebsiella pneumoniae pathogenesis

This study shows that type 2 diabetes mellitus enhances Klebsiella pneumoniae pathogenesis by increasing gut colonization and lung infection severity.