Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PathologybioRxiv
Enhancing Bone Regeneration and Osseointegration using rhPTH(1-34) and Dimeric R25CPTH(1-34) in an Osteoporotic Beagle Model
Jeong-Oh Shin, Jong‐Bin Lee, Sihoon Lee, Jin‐Woo Kim
This study compares the effects of rhPTH(1-34) and dimeric R25CPTH(1-34) on bone regeneration and osseointegration in an osteoporotic beagle model, finding both improve bone parameters with the dimeric analog showing less pronounced but significant benefits.
8 citations - PathologybioRxivPreprint
The Xanthomonas fragariae effector XopK suppresses stomatal immunity by perturbing abscisic acid signaling in strawberry
Xiao-lin Cai, Wenyao Zhang, Haiyan Yu…·Jia-yue Feng
This study identifies XopK, an effector from Xanthomonas fragariae, which suppresses stomatal immunity by disrupting abscisic acid signaling in strawberries, leading to increased susceptibility to infection.
DOI 10.1101/2024.02.07.579334 - PathologyResearch and Practice in Thrombosis and HaemostasisPeer-reviewed
Coagulation activation-induced fibrinolysis biomarker changes depend on thrombophilic risk factors and their clinical phenotype: an interventional in vivo study
Sara Reda, Nadine Schwarz, Jens Müller…·Heiko Rühl
This study examines how fibrinolysis biomarkers change after rFVIIa-induced coagulation activation in patients with thrombophilia, showing prolonged alterations compared to anticoagulant responses.
10 citations - PathologybioRxivPreprint
An image segmentation pipeline optimized for human microglia uncovers sources of morphological diversity in Alzheimer's disease
Robert M. De Jager, Annie J. Lee, Alina Sigalov, Mariko F. Taga
This study develops an image segmentation pipeline to analyze human microglia morphology in Alzheimer's disease, revealing that microglia associated with amyloid plaques have distinct morphological features.
- PathologybioRxivPreprint
A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice
Jackson Wezeman, Martin Darvas, Nadia O. Postupna…·Warren Ladiges
4 citations - PathologybioRxivPreprint
XKidneyOnco: An Explainable Framework to Classify Renal Oncocytoma and Chromophobe Renal Cell Carcinoma with a Small Sample Size
Tahereh Javaheri, Samar Heidari, Xu Yang…·Reza Rawassizadeh
This study introduces an explainable AI framework to differentiate renal oncocytoma from chromophobe renal cell carcinoma with high accuracy, outperforming human experts in some metrics.
- PathologybioRxivPreprint
Cytoarchitecture of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography: imaging workflow and classification for drug testing
Jakob Reichmann, Clement Sarrazin, Sebastian Schmale…·Tim Salditt
The paper develops a workflow for high-throughput X-ray phase contrast tomography to quantify and classify lung cytoarchitecture in SARS-CoV-2 infected hamsters, enabling drug effect analysis.
- PathologybioRxivPreprint
Comparative analysis of kidney transplantation modeled using precision-cut kidney slices and kidney transplantation in pigs
Matthias B. Moor, Johan Nordström, Mikhail Burmakin…·Hannes Olauson
This study compares precision-cut kidney slices (PCKS) with pig kidney transplantation to model ischemia-reperfusion injury, finding that PCKS recapitulates post-reperfusion gene expression patterns seen in human kidney transplantation.
1 citation - PathologybioRxivPreprint
Histological analysis of Scots pine (Pinus sylvestris L.) seedlings in response to root rot pathogen Heterobasidion annosum inoculation
Khaled Youssef, Salla Marttila
This study examines histological responses of Scots pine seedlings to Heterobasidion annosum inoculation and wounding, finding differences in lesion length and resin duct density.
DOI 10.1101/2024.01.17.576084 - PathologybioRxivPreprint
Cross-institutional HER2 assessment via a computer-aided system using federated learning and stain composition augmentation
Chia-Hung Yang, Yung-An Chen, Shao-Yu Chang…·Yen-Yin Lin
This paper develops a HER2 assessment system using federated learning and stain composition augmentation, achieving over 90% accuracy across two institutions with improved generalizability.
- PathologybioRxivPreprint
CD14 Blockade Does Not Improve Outcomes of Deep Vein Thrombosis Following Inferior Vena Cava Stenosis in Mice
Nilesh O. Pandey, Harpreet Kaur, Lakshmi Chandaluri…·Nirav Dhanesha
This study investigates whether CD14 blockade improves DVT outcomes after IVC stenosis in mice, finding no significant effect on thrombus weight, incidence, or neutrophil recruitment.
DOI 10.1101/2024.01.10.575099 - PathologybioRxivPreprint
Alzheimer's disease copathology in dementia with Lewy bodies is associated with astroglial α-synucleinopathy
Hanneke Geut, Emma van den Berg, Baayla D.C. Boon…·Wilma D. J. van de Berg
This study examines how Alzheimer's disease pathology in dementia with Lewy bodies correlates with astroglial α-synucleinopathy and regional differences in pathology load and morphology.
DOI 10.1101/2024.01.02.573857 - PathologyModern PathologyPeer-reviewed
Automated Deep Learning-Based Diagnosis and Molecular Characterization of Acute Myeloid Leukemia using Flow Cytometry
J. E. Lewis, L. A. D. Cooper, D. L. Jaye, O. Pozdnyakova
This paper develops a deep learning pipeline for automated AML diagnosis and molecular characterization using flow cytometry data, achieving high accuracy in classification and variant prediction.
DOI 10.1016/j.modpat.2023.100373 - PathologyLecture notes in computer sciencePeer-reviewed
Enhancing Whole Slide Image Classification with Discriminative and Contrastive Learning
Peixian Liang, Hao Zheng, Hongming Li…·Yong Fan A
This study improves whole slide image classification by using discriminative and contrastive learning to create WSI-level positive and negative samples, enhancing classification performance and feature robustness.
3 citations - PathologyInternational Journal of Molecular SciencesPeer-reviewed
Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis
S. Rachagani, E. Jean Wilson, N. Sirpu Natesh…·J. Subbiah
This study shows red cabbage juice modulates gut microbiota to improve intestinal homeostasis and reduce colitis in mice by enhancing SCFA production and suppressing inflammatory pathways.
DOI 10.3390/ijms25010539 - PathologybioRxivPreprint
Neutrophil Extracellular Traps Drive a skin-kidney inflammatory axis in UVB-Irradiated Lupus-Prone Mice
Xing Lyu, Minghui Li, Ping L. Zhang…·Ming‐Lin Liu
This study identifies a skin-kidney inflammatory axis driven by UVB-induced NETosis in lupus-prone mice, highlighting PKC and CXCR4 as therapeutic targets.
1 citation - PathologyScience AdvancesPeer-reviewed
A Vibrating Ingestible BioElectronic Stimulator Modulates Gastric Stretch Receptors for Illusory Satiety
S. Srinivasan, A. A. Alshareef, A. Hwang…·G. Traverso
The paper develops an ingestible device that activates gastric stretch receptors to reduce food intake and weight gain in swine.
DOI 10.1126/sciadv.adj3003 - PathologyPLOS PathogensPeer-reviewed
A fungal RNA-dependent RNA polymerase is a novel player in plant infection and cross-kingdom RNA interference
A.-P. Cheng, B. Lederer, L. Oberkofler…·A. Weiberg
This study identifies a fungal RNA-dependent RNA polymerase essential for cross-kingdom RNAi and pathogenicity in plant infection.
DOI 10.1371/journal.ppat.1011885 - PathologybioRxivPreprint
Aerosolized α1 adrenoreceptor antagonism does not affect experimentally induced lung fibrosis in animal models
Alexander Ghincea, Carrighan Perry, Angela Liu…·Huanxing Sun
This study tests if inhaled terazosin, an α1 adrenoreceptor antagonist, reduces lung fibrosis in animal models but finds no significant effect.
DOI 10.1101/2023.12.12.571378