Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation
Cyrine Ben Dhaou, Zaki Al‐Yafeai, G Ali Cruz-Marquez, Matthew L. Scott, Brenna H. Pearson, Elizabeth D Cockerham, Hanna Li, Jonette M. Peretik, Yuning Hong, Nirav Dhanesha, Arif Yurdagul, Oren Rom, Md. Shenuarin Bhuiyan, Anthony Wayne Orr
This study shows fibronectin-binding integrins drive ER stress in endothelial cells under atherogenic conditions, promoting inflammation through JNK-c-Jun signaling.
bioRxiv · May 31, 2025 · PreprintPathology