Sihoon Lee

This study shows that the dimeric PTH variant R25CPTH(1-34) activates the PTH1R and improves bone formation in osteoporotic mice.

This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.

This study compares the effects of rhPTH(1-34) and dimeric R25CPTH(1-34) on bone regeneration and osseointegration in an osteoporotic beagle model, finding both improve bone parameters with the dimeric analog showing less pronounced but significant benefits.