Discover, rate, and discuss biology preprints.

This study shows ABHD4 promotes adipocyte differentiation in vitro but does not affect adipose lipid metabolism in mice despite high fat diet.

This paper introduces a heat-based method to improve acid-fast stain detection by eliminating xylene deparaffinization, which damages mycobacterial cell walls.

This study shows adenoviral infection causes arrhythmogenic changes in the heart before significant immune response, through gap junction and ion channel dysfunction.

This paper develops a deep learning model to assess metastatic relapse risk in ER+/HER2-negative breast cancer patients using histological slides, showing improved prognostic performance over clinical factors.

This study identifies a Wnt/β-catenin-PTHrP negative feedback loop that maintains articular cartilage homeostasis and prevents osteoarthritis progression.

This study investigates using deep learning to predict spatial transcriptomics data from whole slide images to assess colorectal tumor metastasis, finding that convolutional networks outperform transformer and graph-based models.

This study evaluates pretraining strategies in an interpretable multimodal deep learning framework for cancer prognosis, showing that pretraining improves performance over standard methods.

This paper develops a deep learning model to predict ERG:TMPRSS2 fusion status in prostate cancer from whole slide images and identifies associated morphological features.

The paper identifies alveolar fibroblasts as the main source of fibroblast subsets involved in lung fibrosis and shows their lineage progression using mouse models and human scRNA-seq data.

This study shows TRPV4 activation protects intervertebral discs from mechanical loading-induced degeneration by enhancing matrix synthesis and reducing inflammation.

This study shows that Syrian golden hamsters exhibit dysregulated alveolar regeneration after SARS-CoV-2 infection, mirroring post-acute sequelae in humans.

This study shows that fibronectin improves calcium signaling and myofilament activation in diabetic cardiomyocytes by enhancing integrin-ECM interactions and mechanical properties.

This study compares machine learning and deep learning methods for Gleason pattern annotation in prostate cancer histology, finding that deep learning better differentiates Gleason patterns.

This study shows that retinoic acid signaling reduces SEM cell formation and atherosclerosis by epigenetically repressing SEM cell marker genes through RAR/EZH2 complex recruitment and histone modification changes.

This study evaluates how three tank-mix additives affect the biological efficacy and phytotoxicity of copper formulations against two fungal pathogens in apple crops.

This study identifies the podocytic IL-15/STAT5 pathway as a protective mechanism in FSGS, showing that IL-15 alleviates glomerular injury by maintaining autophagy.

This study identifies novel small-molecule inhibitors of SARS-CoV-2 main protease that suppress viral replication in human cells.

The paper discovers a new aphid-transmitted rice virus, RTIV, from wild rice plants and shows it causes low-tillering disease in rice cultivars.

This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.