Discover, rate, and discuss biology preprints.

The paper uses Laser Capture Microdissection and RNA sequencing to analyze tissue-specific gene expression in the coral Pocillopora acuta, identifying location-specific functions and highlighting the need for spatial resolution in coral research.

RealKcat predicts enzyme kinetics from sequence using a curated dataset and embeddings, showing sensitivity to catalytic mutations and robustness across evaluations.

This study shows that sialic acid-binding bacterial lectins enhance HIV-1 infectivity in vitro and mucosal transmission in humanized mice by promoting virus-cell attachment and spread.

This study finds that recurrent seizures in epilepsy are associated with reduced cortical entropy in the interictal state, particularly in those with earlier seizure onset.

A RabGAP-fold protein, TBC9, supplies the missing RanGAP activity in Toxoplasma; its acidic C-terminal motif promotes Ran binding and marks TBC9 orthologs across non-ciliate alveolates.

This study uses molecular dynamics simulations to analyze how mutations in ZTA transcription factor affect DNA recognition by rewiring interaction networks and compensatory mechanisms.

This study identifies a soluble cell wall component in Lomentospora prolificans that reduces amphotericin B activity, differing from mechanisms in other fungi.

The paper demonstrates that BBS proteins in frogs bind biliverdin with high affinity, causing NIR fluorescence and contributing to green camouflage.

This study directly observes and quantifies the self-assembly of virus-like particles using mass photometry and single-molecule trapping, revealing the role of multivalent interactions and first-passage dynamics in achieving specific assembly.

The paper investigates how retinotopic map architecture influences the flash-lag effect, showing that FLE distortions depend on motion direction and retinotopic features like meridians and the fovea.

The paper demonstrates that walking speed can be modulated on an adaptive split-belt treadmill through unilateral modifications.

This paper introduces a liquid chromatography-mass spectrometry method to quantify total CoA concentration and isotopic labeling in mouse tissues.

This study uses RNA-seq to analyze gene expression changes in infected earwigs and nematodes, identifying differentially expressed genes and shared transcription factor motifs linked to parasite-induced water-seeking behavior.

The paper investigates how different striatal dopaminergic pathways contribute to visuomotor conditional learning, finding that only nigrostriatal DA is necessary for learning.

This study shows that C4 epidural stimulation in a rodent spinal injury model alters hypoglossal motor output via spinal and peripheral pathways, suggesting potential for restoring swallowing function.

eCOMET integrates metabolomics tools and provides statistical analysis for ecological studies, enabling researchers to assess metabolic diversity and test ecological hypotheses.

The paper reports on the discovery of five emperor penguin breeding locations in West Antarctica, showing significant movement over the last decade and discussing implications for colony dispersal.

The paper shows that Kaposin, a viral lncRNA, remodels nuclear speckles to enhance KSHV gene expression by interacting with repetitive elements.

This study identifies Aminopeptidase N as the receptor for hedgehog merbecoviruses and shows restricted cross-species receptor use.