Arturo Casadevall

Amphotericin B Resistance in Lomentospora prolificans is associated with a soluble cell wall component

This study identifies a soluble cell wall component in Lomentospora prolificans that reduces amphotericin B activity, differing from mechanisms in other fungi.

Strain-specific thermotolerance, UV-C tolerance, and biofilm formation on clinically relevant plastic substrates in the emerging opportunistic pathogen Rhodotorula mucilaginosa

This study compares thermotolerance, UV-C tolerance, and biofilm formation in R. mucilaginosa strains from different origins on medical plastics.

A role for aquaporin (Aqp1) in the control of Cryptococcus neoformans cell morphology

This study investigates the role of Aqp1 in Cryptococcus neoformans cell morphology, finding that its loss leads to smaller cells while overexpression causes enlarged titan-like cells linked to redox physiology and oxidative stress.

Calcium triggers Cryptococcus neoformans aggregation by forming coordination bonds with capsular glucuronoxylomannan

This paper investigates how calcium triggers Cryptococcus neoformans aggregation through coordination bonds with glucuronoxylomannan, revealing its role in capsule structure and host interaction.

Antigen Stimulation Reactivates HIV-1 Proviruses Despite Integration in Repressive Chromatin

This study shows antigen stimulation can reactivate HIV-1 proviruses integrated in repressive chromatin, suggesting deeper latency may contribute to viral rebound.

Stochasticity and Bet Hedging Drive Cryptococcal Capsule Dynamics

This study shows Cryptococcus spp. exhibit stochastic capsule size dynamics, with a bet hedging strategy that balances stress resistance and growth rate.

Fung-AI: An AI/ML-driven pipeline for antifungal peptide discovery

The paper presents a generative AI pipeline for discovering antifungal peptides, identifying five with activity against fungal pathogens and low cytotoxicity.

An Inositol Receptor Orchestrates Carbon Utilization and Fungal Virulence

This study identifies Itr4, a novel inositol transceptor in Cryptococcus neoformans, which regulates inositol and glucose metabolism and fungal virulence.

Metabolic plasticity and virulence of Cryptococcus neoformans are regulated by mitochondrial homeostasis

This study shows that mitochondrial homeostasis in Cryptococcus neoformans affects metabolic plasticity and virulence through the PKA pathway.

The heat-ramp method to study regulated cell death in a pathogenic yeastCryptococcus neoformans

The paper introduces a heat-ramp method to study regulated cell death in Cryptococcus neoformans, revealing a protracted cell death process in pathogenic yeast.

Commonalities and differences in the Cryptococcus neoformans response to ingestion by protozoal and mammalian phagocytic cells suggests host cell metabolism as a target for intracellular survival

This study isolates and characterizes cryptococcal phagosomes from different host cells, revealing conserved fungal responses and suggesting host metabolism as a target for survival.

Fungal proliferation before and after the Cretaceous-Paleogene mass extinction in North America

The paper identifies fungal proliferation in North America before and after the Cretaceous-Paleogene extinction, linking it to climatic cooling and Deccan Traps activity.

Unexpected variability in laboratory and clinical assays used to quantify Cryptococcus neoformans polysaccharide.

This study compares laboratory and clinical assays for measuring cryptococcal polysaccharide, finding that structural variability among strains affects assay sensitivity and results.

A method for authenticating the fidelity of Cryptococcus neoformans knockout collections

The paper identifies mixed plates in a Cryptococcus neoformans knockout collection and proposes an authentication method to distinguish between different KO libraries.

Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden

This study shows dietary L-DOPA increases melanization, immunity, and reduces lifespan in Anopheles mosquitoes, while lowering malaria parasite burden.

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

The Dynamics of Cryptococcus neoformans infection in Galleria mellonella

This study uses timelapse imaging to analyze Cryptococcus neoformans infection dynamics in Galleria mellonella, revealing two distinct mortality phases and deterministic infection progression.

Peroxisomes regulate virulence and cell density sensing in Cryptococcus neoformans

This study shows that peroxisomes in Cryptococcus neoformans regulate virulence and cell density sensing through metabolic pathways and mitochondrial retrograde signaling.

Three annotated chromosome-level de novo genome assemblies of Lomentospora prolificans provide evidence for a chromosomal translocation event

This study presents three chromosome-level genome assemblies of Lomentospora prolificans, revealing a chromosomal translocation event between strains.

New Insights Into The Melanin Structure Of Lomentospora prolificans

This study characterizes melanin in Lomentospora prolificans, revealing multiple melanin types and suggesting a new type synthesized alongside DHN-, DOPA-, and pyomelanin.

Cross-Species Communication via Fungal Extracellular Vesicles

This study examines how fungal extracellular vesicles mediate communication between fungal species and modulate immune responses, revealing their role in virulence and biofilm formation.

The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments

This paper investigates how salinity and polysaccharide rafts affect the buoyancy and persistence of Cryptococcus cells in water, with implications for their transport and pathogenic potential.

Cell wall melanin impedes growth of the Cryptococcus neoformans polysaccharide capsule by sequestering calcium

This study shows that melanin in Cryptococcus neoformans sequesters calcium, impairing polysaccharide capsule formation and leading to increased shed polysaccharide that may affect host immunity.

On the relationship between serotype, chemotype and genotype for Cryptococcus spp. including a method for including polysaccharide structure in strain characterization

This paper examines the relationship between serotype, chemotype, and genotype in Cryptococcus spp., finding no strong correlation between these classifications and GXM motif expression, and introduces a new method for polysaccharide characterization.

Proteins associated with Cryptococcus spp. extracellular polysaccharides are implicated in virulence, capsule integrity, and biofilm formation.

This study identifies four proteins associated with cryptococcal exopolysaccharides that affect virulence, capsule integrity, and biofilm formation through mutant analysis and mass spectrometry.

The Size of Fields in Biomedical Sciences

The paper estimates the size of biomedical research fields by counting unique authors in PubMed publications, finding significant variation in subfield sizes and potential correlations with workforce strength and public health burden.

Human and murine Cryptococcus neoformans infection selects for common genomic changes in an environmental isolate.

The paper shows that environmental Cryptococcus neoformans strains undergo genomic and phenotypic changes during mammalian infection, suggesting animal virulence drives genetic adaptation.

The buoyant cell density of Cryptococcus neoformans is affected by capsule size

The paper investigates how capsule size affects the buoyant cell density of Cryptococcus neoformans and finds that larger capsules reduce cell density, suggesting a role in aquatic dispersal.

Integrin alpha 4/beta 1 (CD49d/CD29) is a component of the murine IgG3 receptor

The paper identifies the integrin alpha4/beta1 as a component of the murine IgG3 receptor, showing its role in mIgG3 binding and phagocytosis.