Caroline Bartman

MYC Suppresses Mitochondrial Function in Hepatocellular Carcinoma through NRF1-Driven Receptor-Mediated Mitophagy

This study shows MYC suppresses mitochondrial function in HCC by promoting mitophagy via NRF1, and inhibiting this pathway reduces tumor growth.

A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling

This paper introduces a liquid chromatography-mass spectrometry method to quantify total CoA concentration and isotopic labeling in mouse tissues.

Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite

The paper identifies soluble sialic acid as a conserved biomarker of inflammation through metabolomics in mouse tissues and cultured macrophages.

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection

This study compares metabolic changes in acute and chronic LCMV infection using metabolomics and isotope tracing, finding more dramatic changes in chronic infection and altered thymidine metabolism as a marker.

Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.

Quantitative fluxomics of circulating metabolites

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.

Transcriptional burst initiation and polymerase pause release are key control points of transcriptional regulation

The paper develops a framework to link Pol II ChIP-seq and single-cell data to transcriptional step rates, showing burst initiation and pause release are key regulated steps, while polymerase binding is not.

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition

The paper tracks Pol II occupancy genome-wide during mitosis-G1 transition and finds a transcriptional spike at the mitosis-G1 transition that exceeds later G1 levels.