Nathaniel W. Snyder

Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism

This study shows that BCAAs are sensed differently by mTOR and c-Myc in T cells, governing proliferation independently of catabolism.

Disconnect Between Succinate, Succinyl-CoA, and Histone Succinylation in Cells and Gastrointestinal Stromal Tumors with Succinate Dehydrogenase Deficiency

This study investigates the metabolic and epigenetic changes in SDH-deficient cells and tumors, finding increased succinyl-CoA but no corresponding increase in histone succinylation or significant effects from desuccinylase inhibition.

Nutrient-sensitive histone propionylation regulates T cell fate and function

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling

This paper introduces a liquid chromatography-mass spectrometry method to quantify total CoA concentration and isotopic labeling in mouse tissues.

SGLT2 inhibitors activate pantothenate kinase in the human heart

This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

This study identifies PDK4 as a regulator of TGF{beta}-mediated SMC contractility, showing that reducing PDK4 limits atherosclerosis by preserving SMC phenotype.

Female-specific m6A remodeling in the liver correlates with post-transcriptional metabolic adaptation to high fat diet

The paper identifies female-specific m6A RNA methylation changes in mouse livers under high-fat diet that correlate with post-transcriptional metabolic adaptations and protein remodeling.

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress

This study shows that reduced myocardial serine synthesis impairs cardiac stress responses by disrupting redox balance, one-carbon metabolism, and amino acid homeostasis.

Histone succinylation directly inhibits Jumonji domain demethylases and stabilizes repressive chromatin states

This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

Synthesis of stable isotope labeled analogs of phytanic acid for separate and combined tracing of alpha-, beta- and omega-oxidation

The paper develops a synthesis method for stable isotope labeled phytanic acid analogs to study alpha-, beta-, and omega-oxidation pathways.

Two-way pantothenate/nitrogen exchange reprograms fly metabolism and reinforces microbiota growth

This study shows Drosophila and their gut bacteria exchange pantothenate for nitrogen, reprogramming fly metabolism and supporting bacterial growth.

Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis

This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

Class I histone deacetylases catalyze lysine lactylation

This paper identifies class I HDACs as enzymes that catalyze lysine lactylation, showing that this modification is primarily formed through enzymatic action rather than non-enzymatic pathways.

Zinc availability in the tumor microenvironment dictates anti-PD1 response in CDKN2ALow tumors via increased macrophage phagocytosis

This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

This study shows that ACSS2-mediated acetate conversion to acetyl-CoA promotes quiescence in ovarian cancer cells, linking metabolic reprogramming to therapeutic resistance.

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.