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This study assesses the pathogenicity of VHL missense mutations using AlphaMissense, protein stability simulations, and molecular dynamics to identify critical regions and mutation effects.

The paper introduces msallsearchpy, a search engine for high-flow quantitative LC-MS proteomics, showing improved identification and quantification performance over existing methods.

The paper shows that inulin supplementation increases colon tumor incidence in mice by altering gut microbiome and metabolome, creating a tumor-promoting environment when exposed to carcinogens.

This study shows MYC suppresses mitochondrial function in HCC by promoting mitophagy via NRF1, and inhibiting this pathway reduces tumor growth.

The paper develops a method using transfer entropy to analyze directional information flow in proteins, identifying key residues involved in allosteric communication and demonstrating its utility in capturing dynamic changes.

The paper characterizes the genome of Teratoramularia rumicicola, identifies functional genes and isolate-specific variations, and highlights potential virulence factors relevant to its use as a microbial herbicide.

This study shows that the E525K β-myosin mutation reduces cardiomyocyte contraction without altering crossbridge cycling, through structural and computational analysis.

The paper identifies a sparse neural code in parrots that enables flexible vocal combinations similar to human speech phonemes.

This study shows that far-red light induces structural changes in cyanobacterial thylakoids, reorganizing antenna-photosystem complexes and revealing persistent membrane heterogeneity.

The paper identifies genetic and environmental factors influencing DNA methylation in ADHD and controls across childhood, showing income and school quality affect methylation changes differently by ADHD trajectory.

This study finds that high-elevation deer mice have reduced baseline fertility and greater sensitivity to hypoxia compared to low-elevation mice, with gene expression changes suggesting adaptive testicular regression.

The paper trains a computer-vision model to identify 16 species of root mealybugs using high-resolution images from museum specimens, achieving 79% F1 score.

This study shows that KSHV vFLIP induces lipid droplet formation in TIME cells via NF-κB activation and ACSL activity.

This study links constricted pupil states to neural replay during wakeful rest in humans, showing their association with motor learning outcomes.

This study uses multiscale multimodal data integration in a mouse model of traumatic brain injury to identify biomarkers of memory deficits and network dedifferentiation.

The paper updates the ModelSEED Biochemistry Database with expanded compounds and reactions, integrating multi-source thermodynamic data and grading reaction reliability.

VO659 reduces multiple neurotoxic mutant huntingtin proteins in Huntington's disease by targeting CAG repeats, while sparing wild-type HTT.

This study investigates the role of AP-1 clathrin adaptor in recycling trans-Golgi network proteins, showing it maintains these proteins in the Golgi during maturation.

This study shows GDF15 helps mice and humans maintain potassium levels by promoting intercalated cell proliferation in response to aldosterone excess.