Discover, rate, and discuss biology preprints.

SPARK quantifies phage-antibiotic interactions using growth curves and shows synergy, antagonism, and dynamic changes across bacterial isolates and time.

This study analyzes phylogenetic resolution differences among Oropouche virus genome segments and identifies sampling biases in publicly available sequences.

The paper develops a causal multiscale model of retinal ERG responses to FLASH and CONV irradiation, evaluates it against data, and predicts dose-response thresholds.

This study benchmarks foundation models for resting-state fMRI time series in cognitive aging, finding mixed results on their utility for cognitive assessment and prediction.

This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.

The paper develops a method to predict phenotype modulation by analyzing amino acid clustering and epistasis in protein sequences, showing that these factors improve prediction accuracy.

The paper quantifies cellular organization and connexin expression in the porcine sinoatrial node, revealing regional differences in pacemaking function and current source-sink relationships.

The paper shows that root-associated microbial communities, including symbiotic and commensal microbes, significantly influence plant responses to elevated CO2 by altering carbon allocation and growth.

This paper introduces a covariate-dependent hidden semi-Markov model to analyze brain network state durations, finding that age and sex influence dwell times in specific brain states.

The paper introduces a dual-reporter assay to screen small molecules for selective inhibition of expanded toxic huntingtin, identifying artifacts and validating compounds.

The paper tests how tree cavities affect bird activity and species richness, finding cavities increase visits and species diversity.

This paper introduces an online deformulating SE-HPLC method to simultaneously quantify total RNA, conjugated antibody, and free antibody in targeted lipid nanoparticles.

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

The paper identifies a ciliogenesis-primed secretory cell state preferentially infected by seasonal H1N1 IAV in human airway epithelium.

This study examines microbial community dynamics in a photobioreactor using agricultural waste gas streams, showing spatially structured communities and partial nitrogen recovery.

This study re-sequences Solenogastres genomes to analyze biomineralization gene evolution, finding reduced SMP gene families and structural proteins in Solenogastres compared to other molluscs.

PEEK integrates silent-mutation and restriction-site engineering with accurate Tm calculations, validated by whole-plasmid sequencing.

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.