Ana Alcaina‐Caro

Network inference at single-cell resolution reveals morphoregulatory divergence and multilayered buffering in limb evolution

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

Conserved Cis-Acting Range Extender Element Mediates Extreme Long-Range Enhancer Activity in Mammals

The paper identifies a conserved cis-acting element, REX, that enables extreme long-range enhancer-promoter interactions in mammals by increasing the genomic interaction range of enhancers.

Increased Enhancer-Promoter Interactions during Developmental Enhancer Activation in Mammals

The paper examines 3D enhancer-promoter interactions during mammalian development, finding that most enhancers bypass neighboring genes and show tissue-specific conformations with increased interactions upon activation.

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

The paper identifies a splicing program in neurons of Drosophila and mammals, showing how it evolves independently in different species to regulate ion channels and neuronal activity.