Discover, rate, and verify biology preprints.

In vivo effects of inducible transgene expression of the age-associated glycogenes St6gal1 and Man1a on epidermal homeostasis

This study investigates the in vivo effects of St6gal1 and Man1a glycogenes on epidermal homeostasis in mice, finding distinct impacts on proliferation, inflammation, and glycosylation patterns.

MHCII+ cancer-associated fibroblasts promote antitumor immunity in pancreatic cancer

This study shows that MHCII+ cancer-associated fibroblasts (CAFs) in pancreatic cancer can promote antitumor immunity through IFNγ-driven mechanisms, counteracting Treg suppression.

Feeding experiments with Senegal bichir Polypterus senegalus provide evidence for diet-related tooth damage and dental microwear

This study shows that diet affects tooth damage and microwear in Senegal bichir, providing a framework for inferring diet in extinct fish species.

Organ scale Three-dimensional atlas of developing pelvic innervation for the mouse lower urinary tract.

The paper creates a 3D atlas of pelvic innervation development in mice, revealing migration patterns, neurogenesis timing, and structural changes in pelvic ganglia across developmental stages.

RAPTORGraph: graph-based pathway modeling for causal discovery in single-cell perturbations

RAPTORGraph improves causal discovery in single-cell perturbations by modeling gene interactions and isolating perturbation effects, outperforming existing methods on downstream analyses.

Four genome assemblies of new wild Gossypium hirsutum accessions from the Yucatan Peninsula, the center of domestication

The paper reports four new chromosome-level genome assemblies of wild Gossypium hirsutum from Yucatan, highlighting their genetic diversity and potential for improving cotton resistance traits.

Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model

The paper develops handheld devices for rapid detection and treatment of subdural hematoma in a sheep model, showing reduced intracranial pressure and improved neurological outcomes.

Replication-coupled maturation of readthrough late transcripts by a polyomavirus small T antigen

This study shows that small T antigen promotes splicing and polyadenylation of viral late transcripts, enhancing gene expression in polyomaviruses.

Factors affecting microbial community composition in Split Lake, MB, Canada

This study examines how environmental factors influence microbial community composition in Split Lake, MB, Canada, identifying six microbial clusters and finding microcystin levels below regulatory limits.

Floral scent diversity and evolution in deceptive Cypripedium, and post-pollination effects on floral scent and its biosynthesis in C. henryi

This study characterizes floral scent diversity in Cypripedium orchids, finds high chemical diversity with weak phylogenetic signal, and shows limited post-pollination effects on scent composition and gene expression in C. henryi.

Can the Human Plastisphere Account for the Rise of Type 1 Diabetes: A Computational Molecular Mimicry Study

This study investigates whether plastic fragments could induce type 1 diabetes through molecular mimicry, using AI and protein structure prediction.

PPI-Rescue: restoration of eye development via functional reconstitution of a transcription complex.

PPI-Rescue restores eye development by reconstituting transcription complexes in Drosophila using targeted mutations and cofactor interactions.

Contributions of Site Heterogeneity in Multi-site Brain-Phenotype Predictions

This paper evaluates how site heterogeneity affects brain-phenotype predictions in multi-site data, finding that larger sample sizes improve accuracy more than multi-site composition.

Discovering Prognostic Risk Strata and Heterogeneous Progression Routes from Cross-Sectional Survival Data

GOTSurv models patient-specific disease progression from cross-sectional survival data, identifying heterogeneous risk strata and individualized progression trajectories without predefined risk cut-offs.

Thalamic stereo-EEG detects sleep stages N2 and N3 with discrimination approaching scalp EEG

This study shows thalamic stereo-EEG can detect sleep stages N2 and N3 with high accuracy, comparable to scalp EEG, using machine learning classifiers.

Functional Screening of Kv7.5 Channel Variants Associated with Neuronal Dysfunction

This study functionally characterizes Kv7.5 channel variants, identifying gain- and loss-of-function effects and proposing a z-score classification for pathogenicity.

Lipidome of Compact Myelin from Cortical Regions of the Aging Murine Brain

The paper analyzes the lipidome of compact myelin from young, middle-aged, and aged mice to identify age-related compositional changes associated with white matter degeneration.

Late radiation-induced brain injury is associated with functional cerebrovascular impairment without structural vessel loss in mice

This study shows that late radiation-induced brain injury in mice causes functional cerebrovascular impairment without structural vessel loss, highlighting endothelial dysfunction as a key factor.

Parallel and lineage-dependent mitonuclear evolution in threespine stickleback

This study examines parallel evolution of nuclear OXPHOS genes in threespine stickleback across freshwater populations and identifies mitonuclear evolutionary coupling in specific functional modules.

Bicarbonate-free pH neutralization resensitizes ovarian cancer to chemotherapy and is tracked by 3T CEST MRI

This study shows that inhibiting MCT1 and MCT4 with acriflavine neutralizes tumor acidosis, restores chemotherapy efficacy, and is monitored by 3T CEST MRI without using bicarbonate.