Hiroaki Tateno

This study investigates the in vivo effects of St6gal1 and Man1a glycogenes on epidermal homeostasis in mice, finding distinct impacts on proliferation, inflammation, and glycosylation patterns.

This study identifies loss of intestinal 1,2-fucose in HIV-treated individuals as a modifiable host-microbiome mechanism linked to inflammation, barrier dysfunction, and aging.

This study shows that inhibiting glycan degradation prevents HIV-induced inflammation, aging, and cognitive impairment in animal models and human cohorts.

This study shows HIV increases sialoglycan expression to engage Siglecs on myeloid cells, promoting immune evasion, and demonstrates that disrupting these interactions enhances immune killing of infected cells.

The paper shows that fucosylation of intestinal mucin determines the entry routes and oral toxicity of botulinum toxin complexes.

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

The paper uses lectin microarrays to analyze glyco-phenotypes of Lacticaseibacillus paracasei mutants, identifying gene functions related to cell surface polysaccharide synthesis.

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

This study introduces scGR-seq, a method combining glycan and RNA analysis in single cells, showing improved cell type separation and identifying lectins specific to hiPSCs and related to neural differentiation.