Discover, rate, and discuss biology preprints.

The paper characterizes bacterial communities in the Bering and Chukchi Seas using 16S rRNA gene sequencing, finding that water mass, salinity, and bloom stage shape community structure.

This study shows that GPCR signaling varies based on submembrane location, with different functional outcomes in cardiomyocytes, and introduces submembrane-specific beta-blockers that target specific nanodomains.

The paper identifies genetically restricted human antibodies that recognize a conserved β-hairpin in postfusion influenza HA and shows that specific IGHV1-2 alleles are required for their production.

This study identifies genomic regions associated with DUS traits in Pakistani wheat varieties using GWAS, aiming to improve varietal identification through molecular markers.

This paper introduces RAD-seq, a method to quantify RNA accessibility by protein binding, and shows it can detect RBP footprints and RNA structure changes under stress.

The paper uses forward genetics and phenotyping to identify genetic factors affecting plant cell proliferative capacity, finding distinct genetic components for different growth traits.

DHARM is an open-source tool that diagnoses, harmonizes, and evaluates batch effects in MRI data using standardized workflows and multivariate diagnostics.

The paper shows that perceived realness is processed in higher dorsal visual areas, not the ventral stream, and is linked to later processing in the intraparietal sulcus.

This study shows that fibrillarin depletion affects henipavirus replication differently across cell types and viruses, and enhances antiviral immune signaling.

The paper identifies a new DarTG subfamily in E. coli that uses a helicase protein to promote ADP-ribosylation of DNA purines, expanding the known functions of helicases in bacterial immunity.

This paper introduces a method to rapidly genotype zebrafish mutants using visual inspection by inserting fluorescent markers into target genes, enabling non-invasive identification of genotypes.

This study identifies water-mass-associated ecotypes of marine Archaea in the Western Arctic Ocean using metagenome-assembled genomes, showing distributions are linked to water mass stratification rather than clade identity.

The paper evaluates amino acid compositional indices for detecting cold adaptation in marine Archaea and finds no evidence of cold adaptation but identifies proteomic signatures linked to sponge host adaptation.

The paper reanalyzes RNA-seq data from neuronal nuclei to identify gene expression changes associated with nuclear TDP-43 loss in FTD and ALS, finding STMN2 depletion and other transcriptomic variations.

The paper identifies widespread readthrough transcription in human cells and shows that depletion of specific factors increases its extent.

This study investigates how norepinephrine and dopamine contribute to strategic decision-making and reward learning in mice, finding distinct roles for each in tracking immediate rewards and longer-timescale strategies.

The paper models cell identity stability using a Markov framework, showing how mixing, competence, and commitment influence transition rates and proposes experiments to test these mechanisms.

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

This paper develops a pneumatic-controlled stop-flow lithography platform to fabricate size-tunable anisotropic multilayered microparticles by regulating flow resistance and minimizing hydraulic compliance.