Helicase family proteins promote antiviral ADP-ribosylation of DNA purines
Trevor Griesman, Adini Q Arifah, Eric J Tomko, Yongjun Tan, Ning Tsao, Jackson T Trotter, Sharvika S Khochare, Nico A Carlson, Nima Mosammaparast, Dapeng Zhang, Eric A Galburt, Constantinos Patinios, Michele LeRoux
The paper identifies a new DarTG subfamily in E. coli that uses a helicase protein to promote ADP-ribosylation of DNA purines, expanding the known functions of helicases in bacterial immunity.
bioRxiv · Nov 3, 2026 · PreprintMicrobiology