Ishwarya Venkata Narayanan

Characterizing nascent readthrough transcripts in human cells

The paper identifies widespread readthrough transcription in human cells and shows that depletion of specific factors increases its extent.

Isoform and pathway-specific post-transcriptional RNA processing in human cells

The paper profiles RNA dynamics in 16 human cell lines using Bru-seq and BruChase-seq, showing gene and pathway-specific RNA turnover and isoform regulation.

Characterizing nascent transcription patterns of PROMPTs, eRNAs, and readthrough transcripts in the ENCODE4 deeply profiled cell lines

The paper identifies nascent transcription patterns of PROMPTs, eRNAs, and readthrough transcripts in 16 human cell lines using Bru-seq and finds they are regulated by sequence and chromatin features, suggesting they are functionally important.

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.