Timothy P.H. Sit

This study investigates how norepinephrine and dopamine contribute to strategic decision-making and reward learning in mice, finding distinct roles for each in tracking immediate rewards and longer-timescale strategies.

This study investigates how mice and monkeys generate stochastic choices in competitive games, finding that neural circuits decouple reward signals from future choices to achieve unpredictability.

This paper identifies a frontal motor circuit that transforms abstract economic decisions into spatial actions through dynamic reconfiguration.

This study examines how Mecp2 deficiency affects microscale cortical network topology and dynamics in a Rett syndrome mouse model, finding slower development and reduced connectivity.

The paper shows that layer 2/3 and layer 5 excitatory neurons in the mouse visual cortex encode visual and nonvisual signals differently, with L2/3 more responsive to visual stimuli and L5 more responsive to movement.

MEA-NAP analyzes microscale functional connectivity and network dynamics from MEA recordings in neuronal cultures, revealing differences in topology and network development.

The paper shows that sound-evoked activity in mouse visual cortex is stereotyped and predictable from behavioral responses, suggesting it arises from low-dimensional internal state signals rather than direct multisensory integration.

The paper shows that mouse frontal cortex combines auditory and visual evidence additively during learning, mirroring behavior, and that this combination is impaired by optogenetic inactivation.

This study shows that cerebral organoids cultured at the air-liquid interface form functional nerve tracts with diverse morphologies and connectivity.