Michele LeRoux

The paper identifies a new DarTG subfamily in E. coli that uses a helicase protein to promote ADP-ribosylation of DNA purines, expanding the known functions of helicases in bacterial immunity.

This study characterizes three A. baumannii phages that use distinct strategies to breach the bacterial capsule, showing how combining phages with different capsule interactions can reduce phage escape mutants.

The paper identifies an orphan antitoxin-like enzyme in phages that neutralizes the bacterial DarTG1 toxin-antitoxin defense system by removing ADP-ribose modifications from phage DNA.