Discover, rate, and discuss biology preprints.

This paper develops a mathematical model to analyze how host stage-structure and ecological factors shape the evolution of parasitoid wasp emergence timing strategies.

This study quantifies lipid sorting during clathrin-mediated endocytosis and finds that lipid asymmetry in the plasma membrane explains observed partitioning, with minimal selectivity for cytoplasmic leaflet lipids compared to non-vesicular trafficking.

Experiment-anchored sweep of p53 abundance thresholds in CPTAC TP53-missense tumors maps how much RHSVV exposure contrast is needed as target coverage falls.

MaveMD provides a clinical interface for MAVE data to classify variants of uncertain significance and improve genetic medicine outcomes.

The paper determines the structure of PTDSS2 from Equus caballus in complex with PE or serine substrates, revealing substrate binding sites and PLD activity.

The paper compares three phytohormone extraction methods in tomato tissues, finding that solid-phase extraction methods do not consistently outperform a simpler single-phase method in reducing matrix effects.

This study shows that Psi RNA binding promotes a conformational change in HIV-1 Gag from compact to extended, essential for viral particle assembly, supported by FRET and molecular dynamics simulations.

The paper introduces non-covalent reversibly photoconvertible fluorescent proteins that change color under illumination, enabling discrimination of spectrally similar variants in live cells.

The paper designs proteins using reduced amino acid alphabets and shows that 8 amino acids can form stable proteins, while smaller alphabets fail in experimental validation.

This paper develops covalent EGFR inhibitors targeting cysteine 775 and 797, showing improved efficacy and resistance delay in osimertinib-resistant models.

This study shows that Bacteroides thetaiotaomicron-derived extracellular vesicles inhibit melanoma growth via immune activation rather than direct cytotoxicity.

The paper uses MD simulations and computational methods to determine the direction of conformational coupling in RTK dimers, showing it correlates with receptor activity states.

This study identifies differentially expressed genes and microenvironmental changes in oral epithelial dysplasia using spatial transcriptomics, highlighting potential regulators of malignant transformation.

This study compares microfluidic droplet technology (MDT) with conventional plate methods (CPM) for isolating Arctic soil microbes, finding MDT significantly improves recovery rates, taxonomic richness, and evenness.

This study compares acute infection and viral rebound dynamics in ART-treated infant rhesus macaques using a mathematical model to identify increased infected cell death during rebound.

This paper identifies and characterizes two β-1,2-xylosyltransferases in Cryptococcus neoformans, showing they differentially impact glycan synthesis and capsule formation.

This study identifies CCNB1IP1 as a regulator of neocortex size and folding in primates, showing its expression increased alongside brain evolution.

This study demonstrates that Vero E6 cells form functional barrier layers with measurable TEER and permeability, comparable to endothelial models, and are sensitive to calcium chelation.

This study shows that zebrafish adapt to protein malnutrition through genome-wide transcriptional changes that enhance intestinal function and survival.

The paper investigates the evolutionary conservation of DELLA protein functions in liverworts and finds GA-independent developmental roles are conserved, but DELLA is not involved in mycorrhizal symbiosis.