Hongyuan Yang

Mechanism of substrate recognition and catalysis in a mammalian phosphatidylserine synthase 2

The paper determines the structure of PTDSS2 from Equus caballus in complex with PE or serine substrates, revealing substrate binding sites and PLD activity.

Autophagy Cargo Profiles in Skeletal Muscle during Starvation and Exercise

The paper develops a method to isolate autophagosomes from mice and uses proteomics to analyze cargo profiles in skeletal muscle during starvation and exercise, identifying distinct cargo selection patterns.

ORP2 regulates free cholesterol accumulation in hepatocytes during MASH

This study shows that ORP2 prevents free cholesterol accumulation in mouse liver, and its absence leads to severe MASH with cholesterol crystals.

PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis

The paper shows PI(4)P recruits CIDE proteins to form unilocular lipid droplets in adipogenesis and hepatic steatosis by interacting with ORP2/5 and PI4K2A.

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

The paper shows hypoxia triggers truncation and constitutive activation of squalene monooxygenase (SM) through proteasomal targeting and substrate accumulation, linking it to oncogenic properties in endometrial cancer.

Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65)

This study shows NEGR1 promotes synaptic targeting of GAD65, affecting GABAergic signaling and feeding behavior in mice.