Author

Zhengnian Li

Stanford MedicineORCID 0000-0001-5851-8011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:virus· 1

Frequent Co-Authors

Nathanael S. GrayiD· 3 shared Eric S. FischeriD· 2 shared Inchul You· 2 shared Jianwei CheiD· 2 shared Katherine A. DonovaniD· 2 shared Tinghu ZhangiD· 2 shared Zixuan JiangiD· 2 shared Antara ChakravartyiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

Nathanael S. GrayORCID

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3 papers

Recent·Most cited

Cancer BiologyACS Central SciencePeer-reviewedSep 29, 2026

Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775

Zhengnian Li, Jie Jiang, Yaning Wang…·Tinghu Zhang

This paper develops covalent EGFR inhibitors targeting cysteine 775 and 797, showing improved efficacy and resistance delay in osimertinib-resistant models.

DOI 10.1021/acscentsci.6c01219

mouseexperimental assay

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Molecular BiologyJournal of the American Chemical SocietyPeer-reviewedNov 5, 2024

Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

Hlib Razumkov, Zixuan Jiang, Kheewoong Baek…·Nathanael S. Gray

The paper identifies CRBN-dependent WEE1 molecular glue degraders through combinatorial library screening and medicinal chemistry, providing structural insights into kinase selectivity.

54 citationstop 1%

experimental assaydrug response / drug discovery

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BiochemistryAdvanced SciencePeer-reviewedAug 15, 2024

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Zhengnian Li, Han‐Yuan Liu, Zhixiang He…·Priscilla L. Yang

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

21 citations

virusexperimental assay

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