The nuclear receptor ROR-alpha is a critical myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor
Raghu Sundaresan Nagalingam, Ju Youn Beak, Logan G. Kirkland, Richard D. Lutze, Wei Chieh Huang, Dhiren Akkina, Mansi Goyal, Christina Kang, Anyue Zhao, Britney G. Alcira, A Aghajanian, Kevin Gerrish, Hong Soon Kang, Anton M. Jetten, Brian C. Jensen
This study identifies ROR-alpha as a critical regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor, through genetic and pharmacologic analyses in mice.
bioRxiv · Jan 12, 2026 · PreprintPhysiology