Anton M. Jetten

This study identifies GLIS3 as a critical regulator of astrocyte differentiation from human neural stem cells, showing its role in gene expression and potential therapeutic relevance.

This study identifies ROR-alpha as a critical regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor, through genetic and pharmacologic analyses in mice.

This study identifies two distinct roles of GLIS3 in β-cell development, showing its critical function in bipotent progenitor generation and preβ-to-β cell differentiation, contributing to neonatal diabetes in GLIS3-deficient mice.

This study shows that RORalpha regulates CaV1.2 expression in the mouse heart through circadian mechanisms, with implications for cardiac function.

This study shows GLIS1 regulates trabecular meshwork function and intraocular pressure, with a human variant linked to glaucoma.

This study shows that RORα regulates mitophagy via caveolin-3 in cardiomyocytes, preserving mitochondrial function and preventing cardiac hypertrophy.