Author

Mansi Goyal

University of North Carolina at Chapel HillORCID 0009-0002-5320-9142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Brian C. JenseniD· 3 shared Logan G. KirklandiD· 3 shared Ju Youn Beak· 2 shared Raghu Sundaresan NagalingamiD· 2 shared Richard D. LutzeiD· 2 shared A Aghajanian· 1 shared Abigail Hockett· 1 shared Amira Ali· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPhysiology

Brian C. JensenORCID

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3 papers

Recent·Most cited

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart

Kelsey H. Fisher‐Wellman, Richard D. Lutze, Logan G. Kirkland, Ju Youn Beak, Mansi Goyal, Raghu Nagalingam, Samantha M. Morrissey, Peyton B. Sandroni, Wei Huang, Julian D. Bailon, Melissa A. Schroder, Lars A. Albrecht, Ethelyn Ofei, Andrew L. Chin, Thomas D. Green, , Brian C. Jensen

This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.

Science Advances · Jul 10, 2026Peer-reviewedPhysiology

Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse Population

Todd Haswell Kimball, Anh N. Luu, Brian Gural, Caitlin Lahue, Abigail Hockett, Sriram Ravindran, Amira Ali, Aryan Dalal, Sam Ardery, Emily L. Sipko, Logan G. Kirkland, Mansi Goyal, Brian C. Jensen, Rebecca B. Berlow, Christoph D Rau

The paper identifies genetic loci associated with heart failure susceptibility and response in mice, highlighting candidate genes that modulate cardiac hypertrophy.

Genetics · Jan 30, 2026Peer-reviewedGenomics

The nuclear receptor ROR-alpha is a critical myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor

Raghu Sundaresan Nagalingam, Ju Youn Beak, Logan G. Kirkland, Richard D. Lutze, Wei Chieh Huang, Dhiren Akkina, Mansi Goyal, Christina Kang, Anyue Zhao, Britney G. Alcira, A Aghajanian, Kevin Gerrish, Hong Soon Kang, Anton M. Jetten, Brian C. Jensen

This study identifies ROR-alpha as a critical regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor, through genetic and pharmacologic analyses in mice.

bioRxiv · Jan 12, 2026 · PreprintPhysiology