Author

Ju Youn Beak

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Brian C. JenseniD· 3 shared Anton M. JetteniD· 2 shared Kevin GerrishiD· 2 shared Logan G. KirklandiD· 2 shared Mansi GoyaliD· 2 shared Raghu Sundaresan NagalingamiD· 2 shared Richard D. LutzeiD· 2 shared A Aghajanian· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPhysiology

Brian C. JensenORCID

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Author profile →

3 papers

Recent·Most cited

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart

Kelsey H. Fisher‐Wellman, Richard D. Lutze, Logan G. Kirkland, Ju Youn Beak, Mansi Goyal, Raghu Nagalingam, Samantha M. Morrissey, Peyton B. Sandroni, Wei Huang, Julian D. Bailon, Melissa A. Schroder, Lars A. Albrecht, Ethelyn Ofei, Andrew L. Chin, Thomas D. Green, , Brian C. Jensen

This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.

Science Advances · Jul 10, 2026Peer-reviewedPhysiology

The nuclear receptor ROR-alpha is a critical myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor

Raghu Sundaresan Nagalingam, Ju Youn Beak, Logan G. Kirkland, Richard D. Lutze, Wei Chieh Huang, Dhiren Akkina, Mansi Goyal, Christina Kang, Anyue Zhao, Britney G. Alcira, A Aghajanian, Kevin Gerrish, Hong Soon Kang, Anton M. Jetten, Brian C. Jensen

This study identifies ROR-alpha as a critical regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor, through genetic and pharmacologic analyses in mice.

bioRxiv · Jan 12, 2026 · PreprintPhysiology

The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating mitophagy through caveolin-3

Ju Youn Beak, Hyun‐Sik Kang, Weichun Huang, Amir Aghajanian, Kevin Gerrish, Anton M. Jetten, Brian C. Jensen

This study shows that RORα regulates mitophagy via caveolin-3 in cardiomyocytes, preserving mitochondrial function and preventing cardiac hypertrophy.

bioRxiv · Oct 2, 2020 · PreprintMolecular Biology