Wei Chieh Huang

This study uses time-resolved single-cell RNA sequencing to identify early endothelial activation and stage-dependent immune-stromal communication in HFpEF progression.

The paper identifies RBBP6-mediated degradation of JUNB as a mechanism causing 3D enhancer-promoter disruption and endothelial dysfunction in diabetes.

This study identifies ROR-alpha as a critical regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor, through genetic and pharmacologic analyses in mice.

This study shows that re-expressing MCM2 in adult cardiomyocytes promotes the secretion of pro-angiogenic cardiosomes, improving cardiac function and reducing fibrosis after myocardial infarction.