Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma
Jingjing Liu, Yang Xu, Mingrui Zhu, Xinran Dong, Honglei Zhou, Brandon M. Bianski, Barbara Jonchère, Wenwei Lin, Xiang Fu, Sheetal Bhatara, Jiyuan Yang, Song-Eun Lim, Lei Yang, Burgess B. Freeman, A Wang, , Jiyang Yu
The paper introduces SINBA, a computational framework that identifies synergistic, brain-penetrant drug combinations for high-risk medulloblastoma, validating several candidates in preclinical models.
bioRxiv · Nov 20, 2025 · PreprintCancer Biology