Lei Yang

Benzopyrene-induced AHR activation in human ESCs primes premature neurogenesis in brain organoids

This study shows that BaP exposure of human ESCs before organoid generation causes premature neurogenesis and morphological defects, which can be reversed by AHR inhibition.

Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma

The paper introduces SINBA, a computational framework that identifies synergistic, brain-penetrant drug combinations for high-risk medulloblastoma, validating several candidates in preclinical models.

rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data

rtmsEcho automates AEMS data processing tasks like peak detection and multimodal analysis, improving efficiency in high-throughput applications.

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Proteomics and ubiquitinomics screening of 100 CRBN ligands in two cell lines validated 50 novel neosubstrates and yielded selective phenyl glutarimide degraders of KDM4B, G3BP2 and VCL.

LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia

This study develops LCK-targeting molecular glues that overcome resistance to kinase inhibitors in T-ALL by inducing CRBN-dependent degradation of LCK.

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.