Giles W. Robinson

Developmental determinants of male bias in medulloblastoma

The paper investigates sex bias in medulloblastoma by analyzing multi-omics data and mouse models, finding that testosterone drives male predominance in this tumor.

Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma

The paper introduces SINBA, a computational framework that identifies synergistic, brain-penetrant drug combinations for high-risk medulloblastoma, validating several candidates in preclinical models.

MODE: high-resolution digital dissociation with deep multimodal autoencoder

MODE improves deconvolution by integrating multi-omic data through a multimodal autoencoder, outperforming existing methods in simulation and real data.

mTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastoma