Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling
Q. Zhou, S. Lyu, A. A. Bertrand, A. C. Hu, C. H. Chan, X. Ren, M. J. Dewey, A. S. Tiffany, B. A. Harley, J. C. Lee
This study shows that increasing stiffness of MC-GAG scaffolds enhances osteogenesis through YAP/TAZ and Wnt signaling, while BMPR signaling is independent of mechanical cues.
bioRxiv · Mar 9, 2020Bioengineering