C. H. Chan

The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer

The paper examines how hypoxia affects the tumor microbiome and its interaction with radiation response in colorectal cancer using RNA-seq data and experimental models.

APLNR marks a cardiac progenitor derived with human induced pluripotent stem cells

The paper identifies APLNR as a surface marker for cardiac progenitors derived from hiPSCs and shows its utility in isolating and differentiating these progenitors into cardiomyocytes and cardiac mesenchyme.

Single amino acid residues control potential-dependent inactivation of an inner membrane bc-cytochrome

The paper identifies single amino acid mutations in CbcL that prevent redox potential-dependent inactivation, allowing growth at higher potentials.

Lack of specificity in Geobacter periplasmic electron transfer

This study shows that multiple triheme periplasmic cytochromes in Geobacter sulfurreducens are promiscuous in electron transfer, supporting metal reduction but not electrode respiration.

Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

The paper determines the structure of OmcZ filaments in Geobacter sulfurreducens, showing they have a distinct heme arrangement compared to OmcS and OmcE, suggesting independent evolution of conductive cytochrome polymers.

Geobacter sulfurreducens inner membrane cytochrome CbcBA controls electron transfer and growth yield near the energetic limit of respiration.

This paper identifies CbcBA as an essential bc-type cytochrome in Geobacter sulfurreducens that regulates electron transfer and growth yield under low redox potential conditions.

Domain Binding and Isotype Dictate the Activity of Anti-human OX40 Antibodies

This study evaluates how isotype and epitope of anti-human OX40 antibodies affect their therapeutic activity in tumor models.

Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling

This study shows that increasing stiffness of MC-GAG scaffolds enhances osteogenesis through YAP/TAZ and Wnt signaling, while BMPR signaling is independent of mechanical cues.

cGAMP signaling controls a transient surface-associated lifestyle

The paper shows that the GacA enzyme in Geobacter sulfurreducens specifically regulates cGAMP levels to control metal reduction genes, despite in vitro promiscuity, through a kinetic model and structural analysis.

Identification of different putative outer membrane electron conduits necessary for Fe(III) citrate, Fe(III) oxide, Mn(IV) oxide, or electrode reduction by Geobacter sulfurreducens

This study identifies different gene clusters in Geobacter sulfurreducens essential for reducing various electron acceptors, showing gene-specific requirements for metal oxides and electrodes.

Genome scale mutational analysis of Geobacter sulfurreducens reveals distinct molecular mechanisms for respiration of poised electrodes vs. Fe(III) oxides

This study uses Tn-Seq to identify genes essential for Geobacter sulfurreducens growth with electrodes versus Fe(III) oxides, revealing distinct molecular mechanisms for electron transfer.