The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates
M. Abdel-Nour, V. Ramaglia, A. A. Bianchi, J. Tsalikis, H. N. Chau, S. K. Kalia, L. V. Kalia, J.-J. Chen, D. Arnoult, J. L. Gommerman, D. J. Philpott, S. E. Girardin
This study shows that HRI enhances autophagic clearance of cytosolic protein aggregates when the UPS is inhibited, and its absence leads to aggregate accumulation and cytotoxicity in both cell and mouse models.
bioRxiv · May 12, 2020Cell Biology