Author

D. J. Philpott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 6 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

S. E. Girardin· 5 shared D. Arnoult· 2 shared A. A. Bianchi· 1 shared A. De Paoli· 1 shared A. J. Baumler· 1 shared A. Klip· 1 shared A. Li· 1 shared A. Mansell· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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5 shared papersCell Biology

S. E. Girardin

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Author profile →

8 papers

Recent·Most cited

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

J. Bruce, L. Li, S. Tang, N. Winsor, S. Keely, D. J. Philpott, S. E. Girardin

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

bioRxiv · Feb 1, 2024 · PreprintCell Biology

Bacterial ADP-heptose initiates a revival stem cell program in the intestinal epithelium

S. Goyal, C. X. Guo, A. Ranger, D. K. Tsang, O. Singh, C. F. Harrigan, O. Zaslaver, H. Rost, H. Y. Gaisano, S. Yuzwa, N. Gao, J. L. Wrana, D. J. Philpott, S. D. Gray-Owen, S. Girardin

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.

bioRxiv · Jan 15, 2024 · PreprintCell Biology

Cytosolic retention of the mitochondrial protease HtrA2 during mitochondrial protein import stress (MPIS) triggers the DELE1-HRI pathway

P. Y. Bi, S. A. Killackey, L. Schweizer, D. Arnoult, D. J. Philpott, S. E. Girardin

This study identifies mitochondrial protein import stress (MPIS) as the trigger for the DELE1-HRI pathway and shows HtrA2 mediates DELE1 cleavage into distinct forms under stress.

bioRxiv · Feb 26, 2023 · PreprintCell Biology

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

P. Boroumand, D. Prescott, T. Mukherjee, P. J. Bilan, M. Wong, J. Shen, I. Tattoli, Y. Zhou, A. Li, T. Sivasubramaniyam, N. Shi, L. Y. Zhu, Z. Liu, C. Robbins, D. J. Philpott, , A. Klip

The paper shows that bone marrow adipocyte whitening during obesity drives the increase of invasive Ly6Chigh monocytes, preceding adipose tissue macrophage expansion.

bioRxiv · Dec 7, 2020Immunology

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

M. Abdel-Nour, V. Ramaglia, A. A. Bianchi, J. Tsalikis, H. N. Chau, S. K. Kalia, L. V. Kalia, J.-J. Chen, D. Arnoult, J. L. Gommerman, D. J. Philpott, S. E. Girardin

This study shows that HRI enhances autophagic clearance of cytosolic protein aggregates when the UPS is inhibited, and its absence leads to aggregate accumulation and cytotoxicity in both cell and mouse models.

bioRxiv · May 12, 2020Cell Biology

Nod-like receptors are critical for gut-brain axis signaling

M. Pusceddu, M. Barboza, M. Schneider, P. Stokes, J. Sladek, C. Torres Fuentes, L. Goldfild, S. Gillis, I. Brust-Mascher, G. Rabasa, K. Wong, C. Lebrilla, M. Byndloss, C. Maisonneuve, A. J. Baumler, , M. Gareau

This study identifies Nod1 and Nod2 as critical regulators of gut-brain axis signaling, showing their role in stress-induced behavioral and physiological changes.

bioRxiv · May 24, 2019 · PreprintPhysiology

NOD1 mediates non-canonical inflammasome processing of interleukin-18 in epithelial cells to Helicobacter pylori infection.

L. S. Tran, L. Ying, K. D'Costa, G. Wray-McCann, G. Kerr, L. Le, C. C. Allison, J. Ferrand, H. Chaudhry, J. Emery, A. De Paoli, S. Creed, M. Kaparakis-Liaskos, J. Como, J. Dowling, , R. L. Ferrero

This study identifies NOD1 as a key regulator of IL-18 processing in epithelial cells during Helicobacter pylori infection, independent of canonical inflammasome proteins.

bioRxiv · Mar 24, 2019 · PreprintImmunology

Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress

R. Molinaro, R. Flick, D. J. Philpott, S. E. Girardin

This study shows that trace peptidoglycan in serum triggers NOD-dependent cytokine responses to ER stress via intracellular Ca2+ changes and endocytosis.

bioRxiv · Feb 13, 2019Immunology