Author

D. Arnoult

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. J. Philpott· 2 shared S. E. Girardin· 2 shared A. A. Bianchi· 1 shared H. N. Chau· 1 shared J. L. Gommerman· 1 shared J. Tsalikis· 1 shared J.-J. Chen· 1 shared L. Schweizer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

D. J. Philpott

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2 papers

Recent·Most cited

Cytosolic retention of the mitochondrial protease HtrA2 during mitochondrial protein import stress (MPIS) triggers the DELE1-HRI pathway

P. Y. Bi, S. A. Killackey, L. Schweizer, D. Arnoult, D. J. Philpott, S. E. Girardin

This study identifies mitochondrial protein import stress (MPIS) as the trigger for the DELE1-HRI pathway and shows HtrA2 mediates DELE1 cleavage into distinct forms under stress.

bioRxiv · Feb 26, 2023 · PreprintCell Biology

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

M. Abdel-Nour, V. Ramaglia, A. A. Bianchi, J. Tsalikis, H. N. Chau, S. K. Kalia, L. V. Kalia, J.-J. Chen, D. Arnoult, J. L. Gommerman, D. J. Philpott, S. E. Girardin

This study shows that HRI enhances autophagic clearance of cytosolic protein aggregates when the UPS is inhibited, and its absence leads to aggregate accumulation and cytotoxicity in both cell and mouse models.

bioRxiv · May 12, 2020Cell Biology