SCRAPPY - a single cell rapid assay of proteome perturbation in yeast uncovers a joint role of aromatic amino acids and oxidative stress in the toxicity of lipophilic nucleoside analogs
E. Ghazy, V. A. Bidiuk, F. Ryabov, O. V. Mitkevich, O. Riabova, Y. M. Stanishevskiy, I. B. Levshin, L. A. Alexandrova, M. V. Jasko, D. A. Makarov, A. A. Zhgun, D. A. Avdanina, A. A. Ermolyuk, V. V. Kushnirov, A. P. Egorova, , A. I. Alexandrov
The paper introduces a single-cell flow cytometry method to assess proteome perturbations in yeast, revealing that aromatic amino acids and oxidative stress jointly contribute to the toxicity of lipophilic nucleoside analogs.
Communications Biology · Apr 27, 2026Peer-reviewedMicrobiology