Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity
K. Rahman, S. A. K. Datta, A. H. Beaven, A. A. Jolley, A. J. Sodt, A. A. Compton
This study shows that cholesterol binds to the amphipathic helix of IFITM3, influencing its antiviral activity by affecting membrane rigidity and fusion pore formation.
bioRxiv · Apr 21, 2022Immunology