A. J. Sodt

Magnesium Transporter MgtA revealed as a Dimeric P-type ATPase

The paper reports the first structure of the Mg2+ transporter MgtA using cryo-EM, revealing its dimeric form and mechanism of Mg2+ transport.

Predicting protein curvature sensing across membrane compositions with a bilayer continuum model

The paper develops a bilayer continuum model to predict how lipid composition affects protein curvature sensing in membranes.

Synaptotagmin 7 C2 domains induce membrane curvature stress via electrostatic interactions and the wedge mechanism

This study investigates how Syt-7 C2 domains generate membrane curvature through electrostatic interactions and the wedge mechanism, using simulations and assays.

Softening in two-component lipid mixtures by spontaneous curvature variance

This study shows that variance in curvature sensitivity of lipids affects membrane stiffness, with coarse-grained models showing greater softening due to clustering.

Kinetic relaxation of giant vesicles validates diffusional softening in a binary lipid mixture

The paper validates that lipid diffusion reduces membrane stiffness in binary lipid mixtures by analyzing undulation relaxation in giant unilamellar vesicles.

Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity

This study shows that cholesterol binds to the amphipathic helix of IFITM3, influencing its antiviral activity by affecting membrane rigidity and fusion pore formation.

Dynamic cholesterol redistribution favors membrane fusion pore constriction

The paper shows cholesterol exclusion from fusion pore necks due to negative curvature, promoting pore closure.

Molecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures

This study uses molecular dynamics simulations to test assumptions about lipid curvature and bilayer mechanics, finding non-additive curvature preferences and two mechanisms of bilayer softening.

Nascent clathrin lattices spontaneously disassemble without sufficient adaptor proteins

This paper quantifies the conditions necessary for stable clathrin assembly on membranes, showing that sufficient adaptor proteins are required to prevent spontaneous disassembly.

The spatial extent of a single lipid's influence on bilayer mechanics

The paper quantifies the spatial influence of individual lipids on membrane mechanics, finding that saturated lipids have non-local effects with maximal interaction strength at a finite length-scale.

An implicit lipid model for efficient reaction-diffusion simulations of protein binding to surfaces of arbitrary topology

This paper introduces an implicit lipid model for efficient reaction-diffusion simulations of protein binding to surfaces of arbitrary topology, showing agreement with explicit lipid models and enabling stable multi-protein complex formation.