Author

A. H. Beaven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:biophysical modeling· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. J. Sodt· 6 shared K. C. Sapp· 4 shared A. A. Compton· 1 shared A. A. Jolley· 1 shared A. E. Matthews· 1 shared A. Hossein· 1 shared H. J. Lessen· 1 shared H. Lin· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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6 shared papersBiophysics

A. J. Sodt

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Synaptotagmin 7 C2 domains induce membrane curvature stress via electrostatic interactions and the wedge mechanism

A. H. Beaven, V. Bikkumalla, N. L. Chon, A. E. Matthews, H. Lin, J. D. Knight, A. J. Sodt

This study investigates how Syt-7 C2 domains generate membrane curvature through electrostatic interactions and the wedge mechanism, using simulations and assays.

bioRxiv · Jan 10, 2024 · PreprintBiophysics

Softening in two-component lipid mixtures by spontaneous curvature variance

A. Hossein, A. H. Beaven, K. C. Sapp, A. J. Sodt

This study shows that variance in curvature sensitivity of lipids affects membrane stiffness, with coarse-grained models showing greater softening due to clustering.

bioRxiv · Dec 12, 2023Biophysics

Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity

K. Rahman, S. A. K. Datta, A. H. Beaven, A. A. Jolley, A. J. Sodt, A. A. Compton

This study shows that cholesterol binds to the amphipathic helix of IFITM3, influencing its antiviral activity by affecting membrane rigidity and fusion pore formation.

bioRxiv · Apr 21, 2022Immunology

Dynamic cholesterol redistribution favors membrane fusion pore constriction

A. H. Beaven, K. C. Sapp, A. J. Sodt

The paper shows cholesterol exclusion from fusion pore necks due to negative curvature, promoting pore closure.

bioRxiv · Apr 15, 2022 · PreprintBiophysics

Molecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures

H. J. Lessen, K. C. Sapp, A. H. Beaven, R. Ashkar, A. J. Sodt

This study uses molecular dynamics simulations to test assumptions about lipid curvature and bilayer mechanics, finding non-additive curvature preferences and two mechanisms of bilayer softening.

bioRxiv · Feb 17, 2022Biophysics

The spatial extent of a single lipid's influence on bilayer mechanics

K. C. Sapp, A. H. Beaven, A. J. Sodt

The paper quantifies the spatial influence of individual lipids on membrane mechanics, finding that saturated lipids have non-local effects with maximal interaction strength at a finite length-scale.

bioRxiv · Jan 20, 2021Biophysics