K. Rahman

Head movement allocation in freely-moving macaques learning object-context sequences

This study examines how freely-moving macaques allocate head movements during learning and memory-guided decision-making in a complex 3D environment using recurrent neural networks.

Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe bats

The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.

Requirement for specific bacterial genome maintenance pathways in repair of C8-linked pyrrolobenzodiazepine (PBD) bi-aryl monomer-mediated DNA damage

This study investigates how C8-linked PBD bi-aryl monomers cause DNA damage in Caulobacter crescentus and identifies the repair mechanisms required for survival.

Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity

This study shows that cholesterol binds to the amphipathic helix of IFITM3, influencing its antiviral activity by affecting membrane rigidity and fusion pore formation.

A calibrated cell-based functional assay to aide classification of MLH1 DNA mismatch repair gene variants

The paper develops a CRISPR-based functional assay to classify MLH1 gene variants by testing their impact on protein function and DNA damage response, generating pathogenicity scores for variants of uncertain significance.

Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

This study identifies a conserved GxxxG motif in IFITM3 that drives oligomerization and antiviral activity by promoting membrane rigidity.

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

A quantitative medico-botanical expedition of Fairy Meadows National Park, Diamir, Gilgit Baltistan, Pakistan

This study documents ethnobotanical knowledge in Fairy Meadows National Park, identifying 90 plant species used for 55 diseases, with new species and uses reported.