Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design
B. Fischer, T. Uchanski, A. Sheryazdanova, S. Gonzalez, A. N. Volkov, E. Brosens, T. Zogg, V. V. Kalichuk, S. Ballet, W. Versees, A. A. Sablina, E. Pardon, A. Wohlkonig, J. Steyaert
The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.
bioRxiv · Dec 6, 2022 · PreprintBioengineering