A. N. Volkov

Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes

This study investigates the role of intrinsic disorder in invariant surface glycoproteins (ISGs) of African trypanosomes, showing they can switch between compact and elongated conformers to balance immune evasion and host interaction.

Structural Insights into the Interaction Between Adenovirus C5 Hexon and Human Lactoferrin

This study presents cryo-EM structures of HAdV-5C hexon and its complex with human lactoferrin, revealing molecular interactions critical for viral entry.

Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.

Vibrio cholerae ParE2 toxin modulates its operon transcription by stabilization of an antitoxin DNA ruler

This study investigates how ParE2 toxin modulates its operon transcription by stabilizing the antitoxin DNA ruler through protein-DNA interactions and structural analysis.

Entropic pressure controls oligomerization of Vibrio cholerae ParD2 antitoxin

This study shows that the intrinsically disordered C-terminal domain of VcParD2 restricts its oligomerization to stable 10-mer or 12-mer structures due to entropic pressure.

Novel anti-repression mechanism of H-NS proteins by a phage "early protein".

This study identifies how phage gp4 modulates H-NS protein MvaT by stabilizing its half-open conformation, relieving gene silencing and affecting P. aeruginosa growth.

Catalysis by a rigid enzyme

The paper shows that the rigid xylanase enzyme uses substrate flexibility to facilitate catalysis without significant structural changes.

Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins

This study identifies the molecular mechanism by which H-NS proteins switch DNA binding states in response to osmotic changes, showing that ionic strength affects electrostatic interactions between domains.