Author

T. Uchanski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

E. Pardon· 3 shared J. Steyaert· 3 shared A. Wohlkonig· 2 shared B. Fischer· 2 shared T. Zogg· 2 shared A. A. Sablina· 1 shared A. N. Volkov· 1 shared A. R. Aricescu· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

E. Pardon

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Author profile →

3 papers

Recent·Most cited

Rapid small-scale nanobody-assisted purification of ryanodine receptors for cryo-EM

C. Li, K. Willegems, T. Uchanski, E. Pardon, J. Steyaert, R. G. Efremov

This paper describes a method to rapidly purify ryanodine receptors from small protein samples for cryo-EM, demonstrating its effectiveness by solving receptor structures.

bioRxiv · Apr 3, 2024Biochemistry

Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

B. Fischer, T. Uchanski, A. Sheryazdanova, S. Gonzalez, A. N. Volkov, E. Brosens, T. Zogg, V. V. Kalichuk, S. Ballet, W. Versees, A. A. Sablina, E. Pardon, A. Wohlkonig, J. Steyaert

The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.

bioRxiv · Dec 6, 2022 · PreprintBioengineering

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

T. Uchanski, S. Masiulis, B. Fischer, V. Kalichuk, A. Wohlkonig, T. Zogg, H. Remaut, W. Vranken, A. R. Aricescu, E. Pardon, J. Steyaert

The paper introduces megabodies, engineered nanobodies that improve cryo-EM resolution by addressing particle size and orientation issues, and demonstrates their application in solving a membrane protein structure.

bioRxiv · Oct 22, 2019Biochemistry