Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions
X. Jin, J. Rosenbohm, A. Ostadi Moghaddam, E. Kim, K. Seiffert-Sinha, M. Leiker, H. Zhai, S. R. Baddam, G. Minnick, Y. Huo, B. Tajvidi Safa, J. K. Wahl, F. Meng, C. Huang, J. Y. Lim, , R. Yang
This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.
bioRxiv · May 3, 2024Biophysics