The paper identifies WNT2B and WNT7B as key ligands maintaining gastric epithelium homeostasis and shows that gastric cancer gains WNT independence through epithelial secretion of WNT7B via MAPK activation.

bioRxiv · Feb 24, 2023 · PreprintCancer Biology

Serum albumin maintains Wnt water-solubility and activity

J. H. Yeo, S. S. Kwon, J. Chae, I. Kusen, J. Han, J. Y. Lim, J.-H. Cheong, T. I. Kim, Y. O. Jung, C. H. Kim, J. Lee

This study identifies serum albumin as a factor that maintains Wnt3a solubility and activity, enabling the development of serum-free Wnt3a preparations for therapeutic use.

bioRxiv · Jan 22, 2023 · PreprintBiochemistry

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

H. Shin, J. E. Park, H. R. Park, W. L. Choi, S. H. Yu, W. Koh, S. Kim, H. Y. Soh, N. E. Waminal, H. R. Belandres, J. Y. Lim, G. Yi, J. H. Ahn, J.-S. Kim, Y.-M. Kim, , J. H. Huh

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

bioRxiv · Sep 28, 2021 · PreprintPlant Biology

The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and Cilia to Regulate Ciliogenesis and Ciliary Protein Traffic

R. E. Turn, Y. Hu, S. I. Dewees, N. Devi, M. P. East, K. R. Hardin, T. Khatib, J. Linnert, U. Wolfrum, J. Y. Lim, J. E. Casanova, T. Caspary, R. A. Kahn

This study identifies ELMOD1 and ELMOD3 as regulators of ciliogenesis and ciliary protein traffic, with phenotypes similar to ELMOD2 deletion but distinct in their effects on Golgi-ciliary transport.

bioRxiv · Sep 15, 2021Cell Biology

Climatic niche conservatism shapes the ecological assembly of Hawaiian arthropod communities

J. Y. Lim, J. Patino, S. Noriyuki, L. C. Simmari, R. G. Gillespie, H. Krehenwinkel

The paper uses a novel metabarcoding approach to study arthropod community diversity along elevation gradients in Hawaii, finding that climatic niche conservatism drives ecological assembly and beta-diversity patterns.

bioRxiv · Jun 22, 2021Ecology

RevGadgets: an R Package for visualizing Bayesian phylogenetic analyses from RevBayes

C. M. Tribble, W. A. Freyman, J. Y. Lim, M. J. Landis, J. Barido-Sottani, B. T. Kopperud, S. Höhna, M. R. May

RevGadgets provides an R package for creating publication-quality figures from Bayesian phylogenetic analyses in RevBayes and other software.

bioRxiv · May 10, 2021Evolutionary Biology

A holobiont view of island biogeography: unraveling patterns driving the nascent diversification of a Hawaiian spider and its microbial associates

E. Armstrong, B. Perez-Lamarque, K. Bi, C. Chen, L. E. Becking, J. Y. Lim, T. Linderoth, H. Krehenwinkel, R. Gillespie

This study examines the evolutionary patterns of a Hawaiian spider and its microbial associates across volcanic islands, finding distinct diversification trends among host spiders, endosymbionts, and gut microbiota.

bioRxiv · Dec 7, 2020Evolutionary Biology

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

J. E. Casanova, R. S. D'Souza, J. Y. Lim, K. Servage, J. Zhang, K. Orth, N. Sosale, M. Lazzara, J. Allegood

The paper identifies a pathway linking calcium influx to focal adhesion turnover during cell migration through the ORP3/IQSec1 complex and Arf5 activation.

bioRxiv · Dec 5, 2019Cell Biology

Nanopore sequencing of long ribosomal DNA amplicons enables portable and simple biodiversity assessments with high phylogenetic resolution across broad taxonomic scale

H. Krehenwinkel, A. Pomerantz, J. B. Henderson, S. R. Kennedy, J. Y. Lim, V. Swamy, J. D. Shoobridge, N. H. Patel, R. G. Gillespie, S. Prost

This study uses long rDNA amplicons sequenced on the MinION platform to enable portable, cost-effective biodiversity assessments with high phylogenetic resolution across broad taxonomic scales.

bioRxiv · Jun 29, 2018Ecology