Y. Huo

Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

This study identifies a tripartite interaction between rice stripe virus, insect salivary carbonic anhydrase, and a plant protein that facilitates virus infection by enhancing callose degradation.

Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.

Disruption of IL-17 signaling in the respiratory mucosa results in invasive streptococcal infection

This study shows that IL-17 deficiency in mice leads to increased S. pyogenes dissemination after respiratory infection, contributing to invasive streptococcal disease.

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

Allele-specific expression links diverse cis-regulatory mutations to recurrent gene dysregulation in high-risk neuroblastoma

The paper uses allele-specific expression analysis in neuroblastoma tumors to identify genes dysregulated by cis-regulatory mutations and copy number alterations.

Increased light availability enhances tolerance against ocean acidification stress in Halimeda opuntia

Increased light availability enhances stress resistance in Halimeda opuntia by the accumulation of soluble organic molecules and enzyme-driven activities to alleviate ocean acidification stress.

Mitochondria fragment and reassemble to initiate the formation and development of the nucleus

The paper shows mitochondria fragment and reassemble to form nuclei and intranuclear inclusions during nuclear development.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

Reversed paired-gRNA plasmid cloning strategy for efficient genome editing in Escherichia coli

This study develops a reversed paired-gRNA plasmid cloning strategy to eliminate plasmid instability caused by direct repeats, achieving efficient genome editing in E. coli.

CRISPR-Cas9-assisted native end-joining editing offers a simple strategy for efficient genetic engineering in Escherichia coli

This paper demonstrates that CRISPR-Cas9-assisted native end-joining editing can efficiently knock out large genomic regions in E. coli without exogenous repair systems.

Age-dependent characterization of the carotid and cerebral artery morphologies in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography

This study characterizes age-related morphological changes in carotid and cerebral arteries of sickle cell anemia mice using ultrasound and micro-CT, finding increased arterial dimensions and narrowing in SS mice.