The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection
A. Chakraborty, A. Bandyopadhaya, V. Singh, F. Kovacic, S. Cha, W. Oldham, A. A. Tzika, L. Rahme
This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.
bioRxiv · Feb 26, 2024Immunology